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Women with a BRCA1 or BRCA2 mutation have a 45-65% chance of developing breast cancer by age 70.[7] BRCA1/2 mutation-carriers have higher breast cancer risk compared with the general population in all age groups.[1] BRCA2-negative women with a BRCA2-carrying first-degree relative may also have increased breast cancer risk, a small UK cohort study showed.[8] Higher sex hormone levels in BRCA mutation carriers may explain some of the increased risk.[9] Breast cancer risk in BRCA mutation carriers may be modified by other factors including family history (breast cancer risk among BRCA2 mutation carriers is 70% higher for each first-degree relative with breast cancer aged 50 or younger, versus BRCA2 mutation carriers with no such family history; breast cancer risk in BRCA1 mutation carriers is not associated with family history),[10] previous breast cancer,[11] and lifestyle factors (indicated by higher risk in BRCA mutation carriers born post-1950 versus pre-1950[12]).

BRCA1 and BRCA2 mutations are uncommon, though this varies by ethnicity/country of origin.[13] They affect an estimated 0.11% and 0.12% of the general population respectively,[14] equating to around 1 in 450 women carrying a mutation.

Please be aware that we will charge £30 for a half day and £60 for a full day course and if the course is oversubscribed we will give priority to professionals working in Bristol.

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Current users of OCs have around 24% higher breast cancer risk compared to never users, a meta-analysis showed.[3] However, breast cancers in OC users tend to be less advanced compared with those in OC never-users.[3] The relative risk of breast cancer declines after OC cessation, such that 10 years after cessation no excess risk remains.[3,4] Breast cancer risk does not appear to increase with longer duration of OC use,[3,4] however, younger age at first OC use is associated with a larger increase in breast cancer risk.[3] The risk associated with OC use appears to be similar across OC formulations (which have changed considerably over time), family history, BRCA carrier status (though some evidence of no association with OC use in BRCA1/2 mutation carriers), and ethnicity.[3,5,6] See IARC's classifications on the role of this risk factor Find out more about the definitions and evidence for this data Learn how attributable risk is calculated View our health information on hormones and cancer International Agency for Research on Cancer (IARC) classifies the role of this risk factor in cancer development.[1] Hormone replacement therapy (HRT) contains synthetic sex hormones, which may explain the link between HRT use and breast cancer risk.

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